Category: Look back at 2006

December 15, 2016 3 min to read

Enzyme’s structure helped elucidate RNAi’s mechanism

Category : Look back at 2006

Study confirmed how RNA-cleaving “Dicer” enzyme measures and then snips its substrates, advancing our understanding of gene silencing Stu Borman Dicer cleaves RNAs (blue strands) into segments roughly the length of its “handle” region. PAZ, RNase IIIa, and RNase IIIb are protein domains, and red spheres are magnesium ions. C...

December 15, 2016 2 min to read

Most-cited chemistry papers published a decade ago

Category : Look back at 2006

C&EN and CAS look back at high-impact research from 2006 Lauren K. Wolf A scanning electron microscope image of graphene flakes. Credit: Capkuckokos/Wikimedia Commons Title: Graphene-based composite materials Reference: Nature, DOI: 10.1038/nature04969 Number of citations: 6,196 Senior authors: SonBinh T. Nguyen and Rodney S. ...

December 15, 2016 2 min to read

Watching protein expression one molecule at a time

Category : Look back at 2006

Single-molecule imaging methods confirmed that gene expression is a random, bursty process Celia Henry Arnaud In 2006, X. Sunney Xie of Harvard University accomplished a rare feat. His group published one paper in Nature and another in Science in the same week. Those papers described the first observations of protein production in li...

December 14, 2016 2 min to read

Scientists smiled with DNA origami

Category : Look back at 2006

Once used to design tiny smiley faces, the nanoscale patterning technique is gaining credibility as a practical tool Bethany Halford Ten years ago, Rothemund used DNA origami to create nanoscale smiley faces. This year he used the technique to recreate a fluorescent dime-sized version of Van Gogh’s “The Starry Night” (shown bel...